PW Series Purified Water System | 250-5,000 L/h | GMP/FDA Compliant

Product Overview

Dual-stage RO system for pharmaceutical-grade purified water production

The PW Series Pharmaceutical Purified Water Treatment System is designed for pharmaceutical, biotechnology, and healthcare facilities requiring USP/EP/ChP-grade purified water. The system uses a double-stage (dual-pass) reverse osmosis process to achieve water quality exceeding pharmacopeia standards.

The complete treatment process includes multi-media filtration, activated carbon adsorption, water softening, cartridge filtration (5 μm), and dual-pass reverse osmosis. The final product water passes through ozone sterilization and 0.22 μm sterilizing filtration before reaching the point of use. UV treatment (254 nm) provides additional bioburden reduction when ozone is not in use.

All pre-treatment stages utilize Fleck automatic control heads (USA) enabling automatic backwashing, forward flushing, and regeneration. The system features self-diagnostic capabilities and automatic protection against low pressure, overpressure, dry run, and other fault conditions. Wetted materials are 316L stainless steel and food-grade PVC-U, fully cGMP compliant.

Meets USP, EP, and ChP purified water standards
Conductivity below 1.1 μS/cm (at 25°C)
75%+ overall water recovery rate
IQ/OQ validation documentation included

PW Series Purified Water System - Process Flow Diagram

Figure 1: Complete PW system process flow - pre-treatment, dual-stage RO, sterilization

How It Works

10-stage treatment process with detailed equipment functions

Raw Water Intake & Tank

The automatic inlet valve opens based on the liquid level signal from the raw water tank. Low/Medium/High level controls manage solenoid valves for safe operation. A manual bypass valve provides emergency backup if the automatic valve fails.

Multi-Media Filtration

A quartz sand filter removes particles larger than 20 μm including silt, rust, colloids, and suspended solids. This protects downstream equipment and extends the service life of subsequent treatment stages. Automatic backwash is triggered by the Fleck control head.

Activated Carbon Adsorption

The activated carbon filter removes pigments, odors, organic matter, residual chlorine (free chlorine <0.1 ppm to protect RO membranes), and pesticide contamination. This critical step protects RO membranes from chlorine damage and improves product water taste and odor.

Water Softening

The softening filter reduces water hardness by removing calcium and magnesium ions (scale-forming) through ion exchange with food-grade resin. Intelligent resin regeneration (Fleck automatic control head) ensures continuous softening capability with minimal maintenance.

Precision Filtration (5 μm)

A 5 μm cartridge filter captures damaged filter media and fine particles that passed through pre-treatment. This protects RO membranes from fouling and ensures required inlet water quality. Replaceable cartridge design for easy maintenance.

First-Stage Reverse Osmosis

Hyde Energy spiral-wound RO membranes treat raw water at 0.8-1.2 MPa operating pressure. Each membrane housing includes a sampling valve for monitoring individual membrane conductivity and performance. First-stage recovery: 50-75% depending on feed water quality.

pH Adjustment & Second-Stage RO

First-stage RO product water enters the pure water tank where food-grade sodium hydroxide (NaOH) adjusts pH to optimal level. The second-stage RO system further polishes water to conductivity below 1.1 μS/cm. Second-stage concentrate is recycled to the raw water tank.

Ozone Sterilization

Ozone (O₃) sterilization provides broad-spectrum biocidal activity against bacteria, spores, viruses, fungi, and protozoa. Ozone leaves no chemical residue and decomposes to oxygen naturally. The dissolved ozone residual maintains microbiological control throughout the distribution loop.

Final Filtration & UV Treatment

A 0.22 μm sterilizing filter (PVDF membrane, hydrophilic) removes dead bacteria, endotoxin fragments, and particles. The 254 nm UV sterilizer provides additional bioburden reduction. Note: UV must be OFF when using ozone - UV converts ozone to oxygen, reducing effectiveness.

Delivery to Use Points

Purified water is delivered through a sanitary 316L stainless steel distribution loop to multiple use points. Continuous circulation maintains water quality. Periodic sanitization cycles (hot water at 80°C or chemical) prevent biofilm formation.

Model Selection Guide

Choose the right capacity for your pharmaceutical water requirements

PW-250

Laboratory & Pilot Scale

250 L/h

purified water

Suitable for labs & pilot plants
Feed water: tap water (TDS <500 ppm)
Compact footprint design
Single-pass RO optional

PW-500

Small-Scale Production

500 L/h

purified water

Best-seller for pharmacies
Dual-stage RO standard
Ozone + UV sterilization
Conductivity <1.1 μS/cm

PW-1000 Best Seller

Medium-Scale Production

1,000 L/h

purified water

Dual-stage RO + EDI optional
Sanitary 316L SS distribution
PLC + HMI full-auto control
IQ/OQ documentation included

PW-5000

Industrial-Scale Production

5,000 L/h

purified water

For large pharma facilities
Multiple RO arrays
SCADA integration available
Turnkey project delivery

Technical Specifications

PW-500 dual-stage RO purified water system (standard configuration)

Parameter	Specification	Notes
System Capacity	500 L/h	At 25°C water temperature (baseline)
Product Water Quality	Pharmacopeia Purified Water	USP/EP/ChP compliant
Conductivity (Product)	<1.1 μS/cm (at 25°C)	Online conductivity meter included
TOC (Total Organic Carbon)	<500 ppb	Optional online TOC analyzer
Raw Water Source	Municipal tap water	TDS <500 ppm recommended
Recovery Rate (1st Stage)	50-75%	Depends on feed water quality
Recovery Rate (2nd Stage)	85-90%	Concentrate recycled to raw tank
Overall Water Recovery	≥75%	Zero liquid discharge design
Pre-Treatment	Multi-media + Carbon + Softener	Fleck automatic control heads (USA)
Cartridge Filter (Pre-RO)	5 μm precision filter	PP wound cartridge, replaceable
RO Membrane Type	Hyde Energy spiral-wound	Polyamide composite, contamination-resistant
RO Operating Pressure (1st)	0.8-1.2 MPa	1.2 MPa = membrane cleaning needed
RO Operating Pressure (2nd)	0.8-1.2 MPa	Adjustable via HP pump VFD
pH Adjustment	Food-grade NaOH dosing	Maintains constant pH level
Sterilizing Filter	0.22 μm PVDF membrane	Removes bacteria, particles >0.22 μm
Ozone Generator	Integrated corona discharge unit	Bacteriolytic-grade sterilization
UV Sterilizer	254 nm wavelength	Additional disinfection layer
Low-Pressure Protection	LPS pressure switch	Prevents pump dry run
Overpressure Protection	HSL pressure switch	System shutdown on overpressure
Control System	PLC + HMI touch screen	Automatic operation, alarms & data logging
Material (Wetted Parts)	316L SS / PVC-U (food-grade)	cGMP compliant construction
Flow Rate Temperature Effect	-2.1% per 1°C below 25°C	Temperature compensation available

* Specifications subject to final confirmation based on site conditions and water quality analysis. Custom capacities from 250 L/h to 5,000 L/h available.

Key Features

Engineered for medical-grade water purity and reliability

Double-Stage RO

Two-pass reverse osmosis ensures product water meets pharmacopeia standards for purified water. Second-stage concentrate is recycled to the raw water tank for zero liquid discharge and 75%+ overall recovery.

Multi-Barrier Sterilization

Ozone sterilization + 0.22 μm PVDF filtration + 254 nm UV treatment provides three layers of protection against bacteria, viruses, endotoxins, and biofilm formation.

Automatic Control

Fleck automatic control heads enable self-backwashing, regeneration, and system diagnostics. Minimal manual intervention required. PLC + HMI for full process automation.

Comprehensive Safety Protection

Low-pressure switch prevents pump dry run. Overpressure switch provides emergency shutdown. Check valves prevent pressure rebound damage. Leak detection sensors throughout.

Real-Time Monitoring

Individual RO membrane sampling valves allow real-time conductivity monitoring. HMI displays flow rates, pressure, temperature, conductivity, ozone residual, and alarm history.

Water Recovery

Second-stage RO concentrate is returned to the raw water tank for recycling. System achieves overall water recovery of 75% or higher, minimizing wastewater disposal costs.

pH Adjustment

Integrated pH adjustment with food-grade sodium hydroxide maintains optimal water chemistry. Online pH and conductivity meters provide continuous quality feedback.

Easy Maintenance

Modular cartridge filters, quick-connect fittings, and self-maintenance system minimize downtime and operating costs. All wear parts catalogued in the manual with replacement intervals.

Applications

Trusted across pharmaceutical and healthcare industries worldwide

Pharmaceutical Manufacturing

Production of oral solid dosage forms, topical preparations, and other drug products requiring pharmacopeia-grade purified water.

Injectable Pre-Treatment

Pre-treatment stage for water for injection (WFI) systems, dialysis centers, and sterile manufacturing facilities requiring the highest water purity.

Hospital Pharmacy

Central pharmacy water systems for compounding, IV admixture preparation, and sterile product manufacturing meeting hospital pharmacy standards.

Laboratory & Research

Quality control laboratories, R&D centers, and analytical testing facilities requiring high-purity water for reagent preparation.

Biotechnology

Cell culture media preparation, buffer solution production, and bioprocessing applications requiring endotoxin-free water.

Nutraceuticals

Dietary supplement manufacturing, health product production, and functional food processing meeting GMP standards.

Why Choose YohoAI?

Your trusted partner in pharmaceutical water treatment

Free Installation & Commissioning

We provide free on-site installation, debugging, and commissioning. Sufficient spare parts, tools, and accessories are included in every shipment.

One-Year Warranty

All products include a 12-month warranty covering parts and labor. During the warranty period, technical services, repairs, and parts replacement are fully covered.

IQ/OQ Validation Support

We provide IQ/OQ/PQ validation documentation, FAT/SAT protocols, material certificates (3.1/3.2), and engineering support for regulatory submissions.

Free Technical Training

We provide free operator training, maintenance training, and process trials at our Shanghai factory. Our engineers support facility layout design.

YohoAI PW Series Purified Water System - GMP/FDA Compliant

What Our Clients Say

Real feedback from Pharmaceutical Purified Water System operators worldwide

★★★★★

"The PW-2000 system consistently produces USP-grade purified water. Real-time monitoring and alerts are excellent. Validation support from YohoAI saved us months of work."

Dr. Fatima A.

Validation Manager, Gulf Pharma Saudi Arabia

Verified ✓

★★★★★

"Installation was smooth. The system integrates perfectly with our existing distribution loop. Water quality has been flawless since startup 2 years ago."

Carlos M.

Engineering Director, Farmacia SA

Verified ✓

All testimonials verified — shared with client permission

Frequently Asked Questions

What water quality does the purified water system produce?

The system produces pharmacopeia-grade purified water that meets USP, EP and ChP standards for pharmaceutical use. Its dual-stage RO with ozone or UV sterilization keeps conductivity below 1.1 uS/cm at 25 C, giving reliable water for tablets, injections and equipment cleaning.

How often do RO membranes need cleaning?

Chemical cleaning is triggered when operating pressure climbs to 1.2 MPa versus 0.8 MPa for new membranes. Under normal feed-water conditions this usually happens every 6 to 12 months, and every membrane housing has a sampling valve for on-site performance monitoring.

How does temperature affect production capacity?

For every 1 C drop below 25 C, production flow falls by about 2.1%. The PW-500 is rated at 500 L/h at the 25 C baseline, so colder feed water reduces hourly output and you should size for your lowest winter temperature.

Can I use UV and ozone sterilization together?

No. UV lamps at 254 nm convert ozone back to oxygen and lower ozone's sterilization effect, so run UV or ozone at one time, not both. Use UV for continuous loop control and ozone for periodic sanitization of the tank and distribution piping.

What is the water recovery rate?

First-stage RO recovery is 50-75% and the second stage is 85-90%. The second-stage concentrate returns to the raw-water tank, lifting overall system recovery to 75% or higher and cutting feed-water use per litre of product water, which lowers operating cost and wastewater.

What certifications and standards does the purified water system meet?

Every system is CE Certified and built to ISO 9001:2015 with cGMP-compliant 316L stainless-steel construction. It meets GMP and FDA expectations plus pharmacopeia standards USP, EP and ChP, and ships with full IQ/OQ/PQ validation documentation so customers pass audits with confidence.

How much does a purified water system cost?

Prices typically range USD 15,000-50,000 for a 250-1,000 L/h skid and USD 80,000-200,000 or more for 5,000-10,000 L/h plants with EDI. Final cost depends on capacity, sterilization method and the depth of IQ/OQ/PQ validation support your site needs before handover.

Which purified water model fits my production scale?

Choose the PW-500 at 500 L/h for pilot lines and small batches, mid-range PW units at 1,000-2,000 L/h for scale-up, and 5,000 L/h systems for full commercial output. Custom skids serve larger sites beyond the standard 5,000 L/h ceiling, with EDI added for low conductivity.

How do I size and select a purified water system?

Size by peak hourly demand plus a safety margin, then verify recovery, conductivity and validation needs. A properly sized RO at 75% recovery yields PW at 1-5 uS/cm, and adding EDI polishes it below 0.5 uS/cm for sensitive injections and other high-grade pharmaceutical products.

What is the lead time and installation timeline?

Standard systems typically ship in 30-60 days after order confirmation, with on-site installation and commissioning finished in about 5-10 days. YohoAI includes free operator training and a 12-month warranty covering parts and labour on every purified water system we deliver.

PW Series Purified Water Treatment System

Product Overview

Process Flow

How It Works

Raw Water Intake & Tank

Multi-Media Filtration

Activated Carbon Adsorption

Water Softening

Precision Filtration (5 μm)

First-Stage Reverse Osmosis

pH Adjustment & Second-Stage RO

Ozone Sterilization

Final Filtration & UV Treatment

Delivery to Use Points

Model Selection Guide

PW-250

PW-500

PW-1000 Best Seller

PW-5000

Technical Specifications

Process Flow Diagram

See It in Action

Key Features

Double-Stage RO

Multi-Barrier Sterilization

Automatic Control

Comprehensive Safety Protection

Real-Time Monitoring

Water Recovery

pH Adjustment

Easy Maintenance

Applications

Pharmaceutical Manufacturing

Injectable Pre-Treatment

Hospital Pharmacy

Laboratory & Research

Biotechnology

Nutraceuticals

Why Choose YohoAI?

Free Installation & Commissioning

One-Year Warranty

IQ/OQ Validation Support

Free Technical Training

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What Our Clients Say

Ready to Start Your Purified Water Project?

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Frequently Asked Questions

What water quality does the purified water system produce?

How often do RO membranes need cleaning?

How does temperature affect production capacity?

Can I use UV and ozone sterilization together?

What is the water recovery rate?

What certifications and standards does the purified water system meet?

How much does a purified water system cost?

Which purified water model fits my production scale?

How do I size and select a purified water system?

What is the lead time and installation timeline?

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