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How to Choose a Softgel Encapsulation Machine

A practical guide to capsule shells and shapes, RG capacity from lab to mega-scale, servo dosing accuracy, GMP materials, and matching RG-100/300/500/8800 models to your output.

CEcGMPISO 9001:2015FDA 21 CFR Part 11

1. Start With Your Product Form

Softgel (soft capsule) encapsulation is ideal for oils, suspensions, and pastes - fish oil, vitamins, coenzyme Q10, and other oxygen-sensitive actives. Confirm your fill matrix first, because it drives pump type and drying parameters rather than machine size.

2. Capsule Shell & Shape

GelatinHPMCPullulanOvalOblongRoundCylindrical

YohoAI RG lines support gelatin, HPMC, and pullulan shells in sizes 5-24 mm (custom 3-30 mm). Vegetarian HPMC and pullulan enable halal and kosher clean-label lines. Die rolls swap in 15-30 minutes across multiple shapes.

3. Capacity: Lab to Mega-Scale

RG-100
5-10k/hr

Lab, min batch 500

RG-300
20-30k/hr

Pilot, up to 40k opt

RG-500
40-60k/hr

Industrial 24/7

RG-8800
228k/hr

Mega-scale multi-die

4. Filling Accuracy & Dosing

A servo-controlled gear pump delivers +/-2% accuracy, with an optional precision flow meter reaching +/-1% for high-value actives. In-process weight control and automatic reject protect batch consistency on every run.

5. Changeover & Batch Size

Tool-free die-roll swaps take 15-30 minutes across multiple capsule shapes, and minimum batch sizes start at 500 capsules on the RG-100 for formulation screening and bioavailability studies.

6. GMP Materials & Construction

All product-contact surfaces are 316L stainless steel with Ra <=0.4 um, CIP-compatible, with full DQ/IQ/OQ/PQ documentation. Certifications: CE, cGMP, ISO 9001:2015.

7. Drying & In-Line Quality

Encapsulated capsules dry at 25C and 30% RH over 4-8 hours. The RG-8800 adds integrated vision and weight-check stations with automatic reject of off-spec capsules, plus MES-ready data logging for mega-scale plants.

8. Match Yoho RG Models

Start on the RG-100 for R&D, scale to RG-300 for pilot, RG-500 for commercial 24/7, and RG-8800 for contract-manufacturing mega-volume with integrated inspection.

ModelTypeCapacityCapsule sizeBest for
RG-100Lab rotary die5-10k caps/hr5-24 mmR&D, screening
RG-300Pilot20-30k (40k opt)5-24 mmPilot, mid volume
RG-500Industrial40-60k caps/hr5-24 mmCommercial 24/7
RG-8800Multi-die228k caps/hr5-24 mmMega-scale, contract
YohoAI RG Series softgel encapsulation machine

Frequently Asked Questions

What is the RG series used for?

The RG series performs softgel (soft capsule) encapsulation of oils, suspensions, and pastes - fish oil, vitamins, CoQ10, and other actives - using rotary die technology. It is the right choice when the fill is liquid or semi-liquid rather than powder. RG lines cover lab screening through mega-scale contract manufacturing on one platform.

What capacity do I need?

RG-100 runs 5-10k caps/hr for labs with a 500-capsule minimum batch, RG-300 reaches 20-30k/hr (40k optional) for pilot, RG-500 delivers 40-60k/hr for commercial 24/7, and RG-8800 hits 228k/hr for contract mega-volume. A single shift at 30k/hr yields about 240,000 capsules, so size for your peak month.

What capsule sizes and shapes are possible?

RG lines handle sizes 5-24 mm, custom 3-30 mm, in oval, oblong, round, and cylindrical shapes. Shells can be gelatin, HPMC, or pullulan, with die-roll swaps in 15-30 minutes across formats. This flexibility lets one line serve multiple SKUs and clean-label vegetarian products without new tooling.

What is the dosing accuracy?

A servo-controlled gear pump gives +/-2% accuracy, with an optional precision flow meter reaching +/-1% for high-value actives. In-process weight control and automatic reject maintain batch consistency on every run. Minimum batch sizes start at just 500 capsules on the RG-100, ideal for formulation screening.

Is the equipment GMP certified?

Yes. Product-contact parts are 316L stainless steel with Ra <=0.4 um, CIP-compatible, and every machine ships with DQ/IQ/OQ/PQ protocols. RG lines are CE marked, cGMP, and ISO 9001:2015 certified. The RG-8800 additionally provides MES-ready data logging for large-scale audit-driven plants.

How fast is die changeover?

Tool-free die-roll swaps take 15-30 minutes across multiple capsule shapes and sizes. The RG-100 supports minimum batches of 500 capsules, ideal for formulation screening and bioavailability studies. Quick changeover lets contract manufacturers switch client formulations within a single shift without losing production days.

Do you support vegetarian and clean-label shells?

Yes. Standard HPMC and pullulan shell support enables halal and kosher clean-label supplement lines in addition to conventional gelatin, all on the same RG platform. Vegetarian shells are processed with the same servo dosing and sealing, so clean-label SKUs do not require a separate machine.

What about drying and inspection?

Capsules dry at 25C and 30% RH over 4-8 hours in a controlled tumble zone. The RG-8800 adds integrated in-line vision and weight-check stations with automatic reject of off-spec capsules, plus MES-ready data logging. Nitrogen flushing and leak-proof sealing protect oxygen-sensitive omega-3 and CoQ10 actives.

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